Transaminase Enzyme Activity and Histopathology Evaluation of Rat’s Liver Induced by DMBA with Temulawak Extract (Curcuma xanthorrhiza)

Temulawak rhizome (Curcuma xanthorrhiza) contains curcumin and xanthorrhizol, which may be used as breast cancer drugs hepatoprotection. This study aims to analyze the activity of alanine aspartate transaminase enzymes histopathological picture 7,12-Dimethylbenz(α)anthracene (DMBA)-induced rat liver due administration temulawak extract. 28 female white rats, divided into seven treatment groups, a control group (normal DMBA) induced by extract orally with doses 35, 70, 140, 210, 280 mg/kg Body Weight (BW) during 11-week period. The results obtained were that application had significant effect on (ALT) levels but did not differ between groups. Aspartate (AST) differed at 35 BW dose. dose 140 BW, De Ritis ratio normal values. analysis showed hepatocyte repair sinusoidal dilatation less than optimal BW. concluded insignificant difference in ALT value. AST value significantly administering controls is expected improve healing damaged carcinogenic substances.